夏斌 博士

北京大学 生命科学学院 教授 博士生导师

北京大学 化学与分子工程学院 教授 博士生导师

北京核磁共振中心 主任兼首席科学家

Bin Xia, PH.D.

Cheung Kong Professor, Peking University

Director and Chief Scientist, Beijing NMR Center

 

个人简历:
   
2001至今
北京核磁共振中心
主任及首席科学家
北京大学
长江特聘教授
北京大学 化学与分子工程学院 分析化学专业
博士生导师
北京大学 生命科学学院 生物化学与分子生物学专业
博士生导师
1997-2001
美国 The Scripps Research Institute
分子生物学系
博士后
1989-1997
美国 University of Wisconsin-Madison
生物物理学 博士
1985-1989
北京大学 生物系
生理学及生物物理学 学士
 
联系方式:

Phone010-6275-8127
Fax
 010-6275-3790
E-mail
binxia@pku.edu.cn

研究兴趣:

利用核磁共振(NMR)技术,结合其它生物化学及分子生物学手段,研究生物大分子结构及其相互作用,以期理解其结构-功能关系,揭示其作用的分子机理。目前主要的研究对象包括细胞凋亡因子Bcl-xL、抑癌基因HREV-107家族蛋白、结核杆菌nucleoid protein Lsr2、SARS病毒主蛋白酶等。

We are interested in studying 3D structures of proteins and their interactions with other proteins, nucleic acids, and small molecule ligands, using NMR spectroscopy along with other techniques in biochemistry and molecular biology, aiming to reveal protein structure-function relationship and molecular mechanisms for protein functions, including the roles of anti-tumor gene HREV-107 family proteins in cell death, the structural basis of bacterial nucleoid-associated proteins in transcription regulation, the function of pro-apoptotic protein Bcl-XL in autophagy, the mechanism of glutaredoxins in iron and oxygen sensing, and protein folding and structural fluctuations using SARS-CoV main protease as a model.


近年代表性文献:

  1. B. Ouyang, L. Wang, S. Wan, Y. Luo, L. Wang, J. Lin, B. Xia*. "Solution structure of monomeric human FAM96A".J Biomol NMR, 56, 387-92(2013)
  2. X. Kang, N. Zhong, P. Zou, S. Zhang, C. Jin, B. Xia*. "Foldon unfolding mediates the interconversion between Mpro-C monomer and 3D domain-swapped dimer".Proc Natl Acad Sci U S A,84, 9721-8 (2012)
  3. K. Zhang, Z. Wang, X. Liu, C. Yin, Z. Basit, B. Xia*, W. Liu*. "Dissection of influenza A virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain".PLoS One,7,e37786(2012).
  4. B. R.G. Gordon, Y Li, A. Coteb, M. T. Weirauch, P. Ding, T. R. Hughes, W. W. Navarre, B. Xia*, and J. Liu* “Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins” Proc. Natl. Acad. Sci. in press (2011)
  5. B. Xia* and X. Kang “Activation and Maturation of SARS-CoV Main Protease”, Protein Cell 2: 282-90 (2011).
  6. J. Zhou, J. Lin, C. Zhou, X. Deng, & B. Xia* “Cytotoxicity of Red Fluorescent Protein DsRed is Associated with the Suppression of Bcl-xL Translation”, FEBS Lett. 585: 821-7 (2011).
  7. J. Zhou, J. Lin, C. Zhou, X. Deng, & B. Xia* “An improved bimolecular fluorescence complementation tool based on superfolder green fluorescent protein” Acta Biochim. Biophys. Sin. 43: 239-44 (2011).
  8. S. Zhang, N. Zhong, F. Xue, X. Kang, X. Ren, J. Chen, C. Jin, Z. Lou and B. Xia* “3D domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease”, Protein Cell 1: 371–83 (2010).
  9. S. Tian, J. Lin, J. Zhou, X. Wan, Y. Li, X. Ren, W. Yu, W. Zhong, J. Xiao, F. Sheng, Y. Chen, C. Jin, S. Li, Z. Zheng, and B. Xia* “Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound Z18”, Autophagy 6: 1032-41 (2010).
  10. X. Ren, J. Lin, C. Jin, and B. Xia* “Solution structure of the N-terminal catalytic domain of human H-REV107 - a novel circular permutated NlpC/P60 domain”, FEBS Lett. 584:4222-6 (2010).
  11. J. Hu, D. Li, X.-D. Su, C. Jin, and B. Xia* “Solution Structure and Conformational Heterogeneity of Acylphosphatase from Bacillus subtilis”, FEBS Lett. 584: 2852-2856 (2010).
  12. J. Lin, N. Wang, Y. Li, Z. Liu, S. Tian, L. Zhao, Y. Zheng, S. Liu, S. Li, C. Jin, and B. Xia* “LEC-BiFC: A New Method for Rapid Assay of Protein Interaction”, Biotech. Histochem. DOI: 10.3109/10520295.2010.483068 (2010).
  13. B. R.G. Gordon, Y. Li , L. Wang , A. Sintsova , H. V. Bakel , S. Tian, W. W. Navarre, B. Xia*, and J. Liu* “Lsr2 is A Nucleoid-Associated Protein that Targets AT-Rich Sequences and Virulence Genes in Mycobacterium tuberculosis”, Proc. Natl. Acad. Sci. 107: 5154-5159 (2010).

 

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